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Jeremiah 21:6

Adam Clarke
Bible Commentary

They shall die of a great pestilence - The sword may appear to be that of man, though I have given the Chaldeans their commission; but the pestilence shall appear to be the immediate act of God.

Albert Barnes
Notes on the Whole Bible

A great pestilence - As the result of the excessive crowding of men and animals in a confined space with all sanitary regulations utterly neglected.

Matthew Henry
Concise Bible Commentary
When the siege had begun, Zedekiah sent to ask of Jeremiah respecting the event. In times of distress and danger, men often seek those to counsel and pray for them, whom, at other times, they despise and oppose; but they only seek deliverance from punishment. When professors continue in disobedience, presuming upon outward privileges, let them be told that the Lord will prosper his open enemies against them. As the king and his princes would not surrender, the people are exhorted to do so. No sinner on earth is left without a Refuge, who really desires one; but the way of life is humbling, it requires self-denial, and exposes to difficulties.