Let then be confounded - Let none of their projects or devices against me succeed. Blast all their designs.
The imprecations in these verses against enemies are all legitimate. They are not against the souls or eternal welfare of those sinners, but against their schemes and plans for destroying the life of an innocent man; and the holiest Christian may offer up such prayers against his adversaries. If a man aim a blow at another with a design to take away his life, and the blow would infallibly be mortal if it took place, and the person about to be slain see that by breaking the arm of his adversary he may prevent his own death, and thus save his enemy from actual murder; it is his duty to prevent this double evil by breaking the arm of the blood-thirsty man. It is on this principle that David prays against his adversaries in the first eight verses of this Psalm.
Let them be confounded - That is, Let them, through Thy gracious interposition in my behalf, be so entirely overcome and subdued that they shall be “ashamed” that they ever made the effort to destroy me; let them see so manifestly that God is on my side that they will be covered with confusion for having opposed one who was so entirely the object of the divine protection and care. See Psalm 6:10, note; Psalm 25:2-3, notes. Compare the notes at Job 6:20.
That seek after my soul - My life. That seek to destroy me.
Let them be turned back - In their attempts to pursue me. Do thou interpose and turn them back.
And brought to confusion - Put to shame; or made ashamed - as they are who are disappointed and thwarted in their schemes.