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I was a reproach - When proscribed at the court of Saul, my enemies triumphed, and loaded me with execrations; my neighbors considered me as a dangerous man, now deservedlJr driven from society; my acquaintance, who knew me best, were afraid to hold any communication with me; and they who saw me in my exile avoided me as if affected with a contagious disorder,

I was a reproach among all mine enemies - That is, he was subjected to their reproaches, or was calumniated and reviled by them. See the notes at Psalm 22:6.

But especially among my neighbors - I was reproached by none more than by my neighbors. They showed special distrust of me, and manifested special unkindness, even more than my enemies did. They turned away from me. They abandoned me. They would not associate with me. They regarded me as a disgrace to them, and forsook me. Compare Job 19:13-15, and the notes at that passage.

And a fear to mine acquaintance - An object of dread or terror, so that they fled from me.

They that did see me without - In the streets, or in public - out of my own house. Not only those in my own dwelling - the members of my family - regarded me in this manner, but passers in the streets - those whom I accidentally met - turned from me and fled in disgust and horror. It is not possible now to determine at what time in the life of the psalmist this occurred, or to ascertain the exact circumstances. There were, doubtless, times when with the saddest feelings he could say that all this was true of him. His troubles in the time of his persecutions by Saul, and still more probably his trials in the time when Absalom rebelled against him, and when he was driven away from his throne and his capital, would furnish an occasion when this would be true. If the latter was the occasion, then we can see how naturally he would connect all this with his “iniquity,” and regard it as the consequence of his sin in the matter of Uriah - a sin which would probably be always in his recollection, and which he would ever onward regard as lying at the foundation of all his afflictions.

David's troubles made him a man of sorrows. Herein he was a type of Christ, who was acquainted with grief. David acknowledged that his afflictions were merited by his own sins, but Christ suffered for ours. David's friends durst not give him any assistance. Let us not think it strange if thus deserted, but make sure of a Friend in heaven who will not fail. God will be sure to order and dispose all for the best, to all those who commit their spirits also into his hand. The time of life is in God's hands, to lengthen or shorten, make bitter or sweet, according to the counsel of his will. The way of man is not in himself, nor in our friend's hands, nor in our enemies' hands, but in God's. In this faith and confidence he prays that the Lord would save him for his mercies's sake, and not for any merit of his own. He prophesies the silencing of those that reproach and speak evil of the people of God. There is a day coming, when the Lord will execute judgment upon them. In the mean time, we should engage ourselves by well-doing, if possible, to silence the ignorance of foolish men.