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Sanctify them - Ἁγιασον, from α, negative, and γη, the earth. This word has two meanings:

1. It signifies to consecrate, to separate from earth and common use, and to devote or dedicate to God and his service.

A minister who engages himself in worldly concerns is a reproach to the Gospel; and he who is not saved from his own sins can with a bad grace recommend salvation to others.

Through thy truth - It is not only according to the truth of God that ministers are to be set apart to the sacred work; but it is from that truth, and according to it, that they must preach to others. That doctrine which is not drawn from the truth of God can never save souls. God blesses no word but his own; because none is truth, without mixture of error, but that which has proceeded from himself. Our Lord still acts here in reference to the conduct of the high priest, to whom it belonged to sanctify the priests, the sons of Aaron: see on John 17:1; (note).

Sanctify them - This word means to render pure, or to cleanse from sins, 1 Thessalonians 5:23; 1 Corinthians 6:11. Sanctification in the heart of a Christian is progressive. It consists in his becoming more like God and less attached to the world; in his getting the ascendency over evil thoughts, and passions, and impure desires; and in his becoming more and more weaned from earthly objects, and attached to those things which are unseen and eternal. The word also means “to consecrate, to set apart to a holy office or purpose.” See John 17:19; also the notes at John 10:36. When Jesus prayed here that God would sanctify them, he probably included both these ideas, that they might be made personally more holy, and might be truly consecrated to God as the ministers of his religion. Ministers of the gospel will be really devoted to the service of God just in proportion as they are personally pure.

Through thy truth - Truth is a representation of things as they are. The Saviour prayed that through those just views of God and of themselves they might be made holy. To see things as they are is to see God to be infinitely lovely and pure; his commands to be reasonable and just; heaven to be holy and desirable; his service to be easy, and religion pleasant, and sin odious; to see that life is short, that death is near; that the pride, pomp, pleasures, wealth, and honors of this world are of little value, and that it is of infinite importance to be prepared to enter on the eternal state of being. He that sees all this, or that looks on things as they are, will desire to be holy. He will make it his great object to live near to God and to glorify his name. In the sanctification of the soul God makes use of all truth, or of everything fitted to make a representation of things as they are to the mind. His Word states that and no more; His Spirit and His Providence do it. The earth and the heavens, the seasons, the sunshine and the rain, are all fitted to teach us his goodness and power, and lead us to him. His daily mercies tend to the same end, and afflictions have the same design. Our own sickness teaches us that we are soon to die. The death of a friend teaches us the instability of all earthly comforts, and the necessity of seeking better joys. All these things are fitted to make just representations to the mind, and thus to sanctify the soul. As the Christian is constantly amid these objects, so he should be constantly growing in grace, and daily and hourly gaining new and deeper impressions of the great truths of religion.

Thy word is truth - All that thou hast spoken - that is, all that is contained in the Bible. All the commands and promises of God; His representations of His own character and that of man; His account of the mission and death of His Son; of the grave, the resurrection, judgment, and eternity, all tend to represent things as they are, and are thus fitted to sanctify the soul. We have here also the testimony of the Saviour that the revelation which God has given is true. All that God has spoken is true, and the Christian should rejoice and the sinner should tremble. See Psalm 19:7-14.

Christ is our model, but unless we behold Him, unless we contemplate His character, we shall not reflect His character in our practical life. He was meek and lowly in heart. He never did a rude action, never spoke a discourteous word. The Lord is not pleased with our blunt, hard, unsympathetic ways toward others. All this selfishness must be purged away from our characters, and we must wear the yoke of Christ. Then we ... shall be fitting up for the society of heavenly angels. We are to be in the world but not of the world. We are to be a representation of Jesus Christ. As the Lord of life and glory came to our world to represent the Father, so we are to go to the world to represent Jesus.³⁶ TMK 306.4

Our only safety is in being joined to the Lord Jesus Christ. We can afford to lose the friendship of worldly men. Those who join themselves to worldly men, that they may carry out their unsanctified purposes, make a fearful mistake; for they forfeit the favor and blessing of God. I am to urge upon the attention of our people that the Lord Himself has placed a wall of separation between the world and that which He has established on the earth. God's people are to serve Him, for Christ has called them out of the world, and sanctified and refined them, that they may do His service.... There is no such thing as maintaining concord between the profane and the holy. There can be no concord between Christ and Belial. But “the Lord hath set apart him that is godly for himself” (Psalm 4:3). And this consecration to the Lord, this separation from the world, is plainly declared and positively enjoined in both the Old and the New Testaments.—Letter 329, December 11, 1905, to J. A. Burden, manager of the Loma Linda Sanitarium. TDG 354.4

Of the zealous, self-sacrificing disciples of Christ, it is written that Jesus was not ashamed to call them brethren, so fully did they manifest His Spirit, and bear His likeness. By their works they constantly testified that this world was not their home; their citizenship was above; they were seeking a better country, even a heavenly. Their conversation and affections were on heavenly things. They were in the world, but not of the world; in spirit and practice they were separate from its maxims and customs. Their daily example testified that they were living for the glory of God. Their great interest, like that of their Master, was for the salvation of souls. For this they toiled and sacrificed, counting not their lives dear unto themselves. By their life and character they made a bright track heavenward. Upon such disciples, Jesus can look with satisfaction as His representatives. His character will not be misrepresented through them.... LHU 325.3

And for their sakes I sanctify myself, that they also might be sanctified through the truth. John 17:19. RC 101.1

Before Jesus went forth to His final conflict with the powers of darkness, He lifted up His eyes to heaven, and prayed for His disciples. He said: “I pray not that thou shouldest take them out of the world, but that thou shouldest keep them from the evil. They are not of the world, even as I am not of the world. Sanctify them through thy truth: thy word is truth.” ... RC 101.2