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Psalms 143:4

Albert Barnes
Notes on the Whole Bible

Therefore is my spirit overwhelmed within me - See the notes at Psalm 77:3. Compare Psalm 42:5-7. His spirit was broken and crushed. He was in a state of despair as to any human help.

My heart within me is desolate - I have no comfort; no cheerfulness; no hope. My soul is like the waste desert where there is no water; where nothing grows; where there are only rocks and sands.