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Let there be none to extend mercy unto him - Let him find compassion and sympathy in no one. When he suffers, let him be left to bear it alone. Let there be none found to shed a tear of compassion over him, or to relieve him. Literally, “Let there be no one to draw out kindness to him.”

Neither let there be any to favor his fatherless children - To show them mercy or kindness. See the notes at Psalm 109:10.

The Lord Jesus may speak here as a Judge, denouncing sentence on some of his enemies, to warn others. When men reject the salvation of Christ, even their prayers are numbered among their sins. See what hurries some to shameful deaths, and brings the families and estates of others to ruin; makes them and theirs despicable and hateful, and brings poverty, shame, and misery upon their posterity: it is sin, that mischievous, destructive thing. And what will be the effect of the sentence, "Go, ye cursed," upon the bodies and souls of the wicked! How it will affect the senses of the body, and the powers of the soul, with pain, anguish, horror, and despair! Think on these things, sinners, tremble and repent.