Fools because of their transgression - This is the Third comparison; the captivity being compared to a person in a dangerous malady. Our Version does not express this clause well: Fools פשעם מדרך midderech pisham, because of the way of their transgressions, are afflicted. Most human maladies are the fruits of sin; misery and sin are married together in bonds that can never be broken.
Fools, because of their transgression - Wicked people, considered as fools, because they “are” transgressors. Compare Psalm 14:1, note; Psalm 73:3, note; Psalm 75:4, note. The immediate allusion here, probably, is to the Jews, who had been so wicked and so supremely foolish in violating the commands of God, and making it necessary to bring upon them as a punishment the captivity at Babylon; but the language is made general because it will with equal propriety describe the conduct of all wicked people. There is nothing more foolish than an act of wickedness; there is no wisdom equal to that of obeying God.
And because of their iniquities, are afflicted - A more literal rendering of this verse would be, “Fools from the way of their transgressions (that is, by their course of transgression), and by their iniquities, afflict themselves.” The idea is, that it is “in the very line” of their trangressions; or, that they “bring it upon themselves.” All punishment is in fact in the line of the offence; that is, sin leads directly to it; or, in other words, if a man treads along in the path of sin, he will come to this result - to punishment. Punishment is not arbitrary on the part of God, and it is not of the nature of a mere direct infliction from his “hand.” It is what people mete out to themselves, and what they might have avoided if they had chosen to do so.
The Scripture says that “men ought always to pray, and not to faint” (Luke 18:1); and if ever there is a time when they feel their need of prayer, it is when strength fails and life itself seems slipping from their grasp. Often those who are in health forget the wonderful mercies continued to them day by day, year after year, and they render no tribute of praise to God for His benefits. But when sickness comes, God is remembered. When human strength fails, men feel their need of divine help. And never does our merciful God turn from the soul that in sincerity seeks Him for help. He is our refuge in sickness as in health. MH 225.1
“Like as a father pitieth his children,
So the Lord pitieth them that fear Him.
For He knoweth our frame;
He remembereth that we are dust.”
MH 225.2