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Proverbs 14:10

Adam Clarke
Bible Commentary

The heart knoweth his own bitterness - נפשו מרת morrath naphsho, "The bitterness of its soul." Under spiritual sorrow, the heart feels, the soul feels; all the animal nature feels and suffers. But when the peace of God is spoken to the troubled soul, the joy is indescribable; the whole man partakes of it. And a stranger to these religious feelings, to the travail of the soul, and to the witness of the Spirit, does not intermeddle with them; he does not understand them: indeed they may be even foolishness to him, because they are spiritually discerned.

Albert Barnes
Notes on the Whole Bible

A striking expression of the ultimate solitude of each man‘s soul at all times, and not merely at the hour of death. Something there is in every sorrow, and in every joy, which no one else can share. Beyond that range it is well to remember that there is a Divine Sympathy, uniting perfect knowledge and perfect love.