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Luke 1:49

King James Version (KJV)
Adam Clarke
Bible Commentary

He that is mighty hath done to me great things - Or, miracles, μεγαλεια . As God fills her with his goodness, she empties herself to him in praises; and, sinking into her own nothingness, she ever confesses that God alone is all in all.

Holy is his name - Probably the word which Mary used was חסד chesed, which though we sometimes translate holy, see Psalm 86:2; Psalm 145:17, yet the proper meaning is abundant goodness, exuberant kindness; and this well agrees with the following clause.

Albert Barnes
Notes on the Whole Bible

He that is mighty - God.

Hath done to me great things - Hath conferred on me great favors and distinguished mercies.

And holy is his name - This is an expression of Mary‘s feelings, desiring to bestow on God all honor and praise. As the highest honor, she declared that his “name” was “holy” - that is, that God was free from sin, injustice, and impurity. The “name” of God is often put for God Himself. The proper name of God is יהוה Yahweha word expressive of His “essential being,” derived from the word “to be,” Exodus 3:14; Exodus 6:3; Psalm 83:18. That name is holy; is to be regarded as holy; and to make a common or profane use of it is solemnly forbidden, Exodus 20:7.

Matthew Henry
Concise Bible Commentary
It is very good for those who have the work of grace begun in their souls, to communicate one to another. On Mary's arrival, Elisabeth was conscious of the approach of her who was to be the mother of the great Redeemer. At the same time she was filled with the Holy Ghost, and under his influence declared that Mary and her expected child were most blessed and happy, as peculiarly honoured of and dear to the Most High God. Mary, animated by Elisabeth's address, and being also under the influence of the Holy Ghost, broke out into joy, admiration, and gratitude. She knew herself to be a sinner who needed a Saviour, and that she could no otherwise rejoice in God than as interested in his salvation through the promised Messiah. Those who see their need of Christ, and are desirous of righteousness and life in him, he fills with good things, with the best things; and they are abundantly satisfied with the blessings he gives. He will satisfy the desires of the poor in spirit who long for spiritual blessings, while the self-sufficient shall be sent empty away.