The isles of Chittim - This is the island of Cyprus, according to Josephus. In 1 Maccabees 8:5, it is taken for Macedonia. Besides this, how they (the Romans) had discomfited in battle Philip and Perseus, king of the Chittims. Chittim was the grandson of Japhet; and Bochart has made it appear that the countries inhabited by the Chittim were Italy and the adjacent provinces of Europe, lying along the coast of the Mediterranean Sea; and probably this is the prophet's meaning.
Send unto Kedar - The name of an Arabian tribe. See if nations either near or remote, cultivated or stupid, have acted with such fickleness and ingratitude as you have done! They have retained their gods to whom they had no obligation; ye have abandoned your God, to whom ye owe your life, breath, and all things!
Kedar signifies the whole East, and the isles of Chittim (Isaiah 23:12 note) the West. If then you traverse all lands from west to east, it will be impossible to find any nation guilty of such apostasy as that committed by Israel.