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Isaiah 6:12

Albert Barnes
Notes on the Whole Bible

And the Lord have removed … - The land shall be given up to desolation. The men - the strength of the nation - shall be taken to a distant land.

And there be a great forsaking - A great desolation; the cities and dwellings shall be abandoned by the inhabitants; compare Isaiah 17:2; Jeremiah 4:29; Zephaniah 2:4.

Matthew Henry
Concise Bible Commentary
God sends Isaiah to foretell the ruin of his people. Many hear the sound of God's word, but do not feel the power of it. God sometimes, in righteous judgment, gives men up to blindness of mind, because they will not receive the truth in the love of it. But no humble inquirer after Christ, need to fear this awful doom, which is a spiritual judgment on those who will still hold fast their sins. Let every one pray for the enlightening of the Holy Spirit, that he may perceive how precious are the Divine mercies, by which alone we are secured against this dreadful danger. Yet the Lord would preserve a remnant, like the tenth, holy to him. And blessed be God, he still preserves his church; however professors or visible churches may be lopped off as unfruitful, the holy seed will shoot forth, from whom all the numerous branches of righteousness shall arise.