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I perceive that this voyage will be with hurt, etc. - Paul might either have had this intimation from the Spirit of God, or from his own knowledge of the state of this sea after the autumnal equinox, and therefore gave them this prudent warning.

Sirs - Greek: Men.

I perceive - It is not certain that Paul understood this by direct inspiration. He might have perceived it from his own knowledge of the danger of navigation at the autumnal equinox, and from what he saw of the ship as unsuited to a dangerous navigation. But there is nothing that should prevent our believing also that he was guided to this conclusion by the inspiration of the Spirit of God. Compare Acts 27:23-24.

Will be with hurt - With injury or hazard. It is not meant that their lives would be lost, but that they would be jeoparded.

The lading - The freight of the ship. It was laden with wheat, Acts 27:38. Paul evidently, by this, intended to suggest the propriety of remaining where they were until the time of dangerous navigation was past.

This question was earnestly discussed, and was finally referred by the centurion to Paul, who had won the respect of both sailors and soldiers. The apostle unhesitatingly advised remaining where they were. “I perceive,” he said, “that this voyage will be with hurt and much damage, not only of the lading and ship, but also of our lives.” But “the master and the owner of the ship,” and the majority of passengers and crew, were unwilling to accept this counsel. Because the haven in which they had anchored “was not commodious to winter in, the more part advised to depart thence also, if by any means they might attain to Phenice, and there to winter; which is an haven of Crete, and lieth toward the southwest and northwest.” AA 441.1

The centurion decided to follow the judgment of the majority. Accordingly, “when the south wind blew softly,” they set sail from Fair Havens, in the hope that they would soon reach the desired harbor. “But not long after there arose ... a tempestuous wind;” “the ship was caught, and could not bear up into the wind.” AA 441.2

Driven by the tempest, the vessel neared the small island of Clauda, and while under its shelter the sailors made ready for the worst. The lifeboat, their only means of escape in case the ship should founder, was in tow and liable to be dashed in pieces any moment. Their first work was to hoist this boat on board. All possible precautions were then taken to strengthen the ship and prepare it to withstand the tempest. The scant protection afforded by the little island did not avail them long, and soon they were again exposed to the full violence of the storm. AA 441.3