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Manasseh was twelve years old - He was born about three years after his father's miraculous cure; he was carried captive to Babylon, repented, was restored to his kingdom, put down idolatry, and died at the age of sixty-seven years. See 2 Chronicles 33:1-20.

Manasseh was twelve years old - Manasseh, therefore, was not born at the time of Hezekiah‘s dangerous illness; and it is probable that Hezekiah had at that time no son to succeed him. According to Josephus, this was the principal cause of his grief.

Hephzibah - Jewish tradition makes Hephzibah, Hezekiah‘s wife, the daughter of Isaiah; but this is scarcely probable. She was, however, no doubt, known to the prophet, and it may well have been in special compliment to her that Isaiah introduced her name Isaiah 62:4 as one that Jerusalem would bear after her restoration to God‘s favor. The name means, “My delight (is) in her.”

Young persons generally desire to become their own masters, and to have early possession of riches and power. But this, for the most part, ruins their future comfort, and causes mischief to others. It is much happier when young persons are sheltered under the care of parents or guardians, till age gives experience and discretion. Though such young persons are less indulged, they will afterwards be thankful. Manasseh wrought much wickedness in the sight of the Lord, as if on purpose to provoke him to anger; he did more evil than the nations whom the Lord destroyed. Manasseh went on from bad to worse, till carried captive to Babylon. The people were ready to comply with his wishes, to obtain his favour and because it suited their depraved inclinations. In the reformation of large bodies, numbers are mere time-servers, and in temptation fall away.