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God hath forsaken him - "God, who has been his special help all through life, and who has guarded him so that no hand could be raised successfully against him, has now cast him off; therefore we shall easily prevail against him. His present adversity shows that God is no longer his friend." Thus men judge. "Secular prosperity is a proof of God's favor: adversity is a proof of his displeasure." But this is not God's way, except in especial judgments, etc. He never manifests his pleasure or displeasure by secular good or ill.

Saying, God hath forsaken him - That is, God has given him over; he no longer protects him; he regards him as a wicked man, and we shall therefore, not only be “safe” in our attempts upon his life, but we shall be “justified” in those attempts.

Persecute and take him - It can be done safely now; it can be done with propriety.

For there is none to deliver him - He has no one now to whom to look; no one on whom he can rely. Abandoned by God and by man, he will be an easy prey. Compare the notes at Psalm 41:7-8.

David prays that he might never be made ashamed of dependence upon God. With this petition every true believer may come boldly to the throne of grace. The gracious care of Divine providence in our birth and infancy, should engage us to early piety. He that was our Help from our birth, ought to be our Hope from our youth. Let none expect ease or comfort from the world. Those who love the Lord, often are hated and persecuted; men wondered at for their principles and conduct; but the Lord has been their strong refuge. The faithful servants of God may be assured that he will not cast them off in old age, nor forsake them when their strength fails.