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There is none to guide her - The image here is taken from the condition of one who is under the influence of an intoxicating draught, and who needs some one to sustain and guide him. The idea is, than among all the inhabitants of Jerusalem in the time of the calamity, there was none who could restore to order the agitated and distracted affairs of the nation. All its wisdom was destroyed; its counsels perplexed; its power overcome.

All the sons whom she hath brought forth - All the inhabitants of Jerusalem.

God calls upon his people to mind the things that belong to their everlasting peace. Jerusalem had provoked God, and was made to taste the bitter fruits. Those who should have been her comforters, were their own tormentors. They have no patience by which to keep possesion of their own souls, nor any confidence in God's promise, by which to keep possession of its comfort. Thou art drunken, not as formerly, with the intoxicating cup of Babylon's idolatries, but with the cup of affliction. Know, then, the cause of God's people may for a time seem as lost, but God will protect it, by convincing the conscience, or confounding the projects, of those that strive against it. The oppressors required souls to be subjected to them, that every man should believe and worship as they would have them. But all they could gain by violence was, that people were brought to outward hypocritical conformity, for consciences cannot be forced.