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How long? - How long shall I continue under this malady? How long will it be before thou speak peace to my troubled heart?

My soul is also sore vexed - The word “soul” here is used in the sense in which it is commonly with us, as denoting the mind. The idea is, that his sorrows were not merely those of the bodily frame. They had a deeper seat than even the bones. His mind, his soul, was full of anguish also, in view of the circumstances which surrounded him, and which had brought on these bodily afflictions.

But thou, O Lord - This is a broken sentence, as if he had commenced an address to God, but did not complete it. It is as if he had said, “Here I suffer and languish; my sorrows are deep and unmitigated; as for thee, O Lord” - as if he were about to say that he had hoped God would interpose; or, that his dealings were mysterious; or, that they seemed strange or severe; but he ends the sentence by no language of complaint or complaining, but by simply asking “how long” these sorrows were to continue.

How long? - That is, how long wilt thou leave me thus to suffer? How long shall my unmitigated anguish continue? How long will it be ere thou wilt interpose to relieve me? The language implies that in his apprehension it was already a long time - as time usually seems long to a sufferer (compare Job 7:2-4), and that he was constantly looking out for God to interpose and help him. This is language such as all persons may be inclined to use on beds of pain and languishing. It seems indeed long to them now; it will, however, seem short when they look back upon it from the glories of the heavenly world. Compare 2 Corinthians 4:17-18.

These verses speak the language of a heart truly humbled, of a broken and contrite spirit under great afflictions, sent to awaken conscience and mortify corruption. Sickness brought sin to his remembrance, and he looked upon it as a token of God's displeasure against him. The affliction of his body will be tolerable, if he has comfort in his soul. Christ's sorest complaint, in his sufferings, was of the trouble of his soul, and the want of his Father's smiles. Every page of Scripture proclaims the fact, that salvation is only of the Lord. Man is a sinner, his case can only be reached by mercy; and never is mercy more illustrious than in restoring backsliders. With good reason we may pray, that if it be the will of God, and he has any further work for us or our friends to do in this world, he will yet spare us or them to serve him. To depart and be with Christ is happiest for the saints; but for them to abide in the flesh is more profitable for the church.