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As they ministered to the Lord, and fasted - On Mondays and Thursdays it was usual with the more pious Jews to attend the public service in their synagogues, and to fast: the former is what we are to understand by ministering to the Lord. On the Sabbaths they attended the service in the synagogue, but did not fast. The Greek word, λειτουργουντων, signifies performing the office of praying, supplicating, rendering thanks, etc.: hence the word λειτουργια, liturgy, the work of prayer, etc., from λιτη, supplication, according to some; or rather from λειτος, common, and εργον, work, the common or public work, in which all the people were engaged.

The Holy Ghost said - A revelation of the Divine will was made to some person then present; probably to either Simeon, or Lucius, or Manaen, mentioned before.

Separate me Barnabas and Saul - Consecrate, or set them apart, for the particular work whereunto I have called them. How this was done, we find in the next verse.

As they ministered to the Lord - It is probable that this took place on some day set apart for fasting and prayer. The expression “ministered to the Lord” means as they were engaged in prayer to the Lord, or as they were engaged in divine service. The Syriac thus renders the passage.

The Holy Ghost said - Evidently by direct revelation.

Separate me - Set apart to me, or for my service. It does not mean to ordain, but simply to designate, or appoint to this specific work.

For the work whereunto I have called them - Not the apostolic office, for Saul was called to that by the express revelation of Jesus Christ Galatians 1:12, and Barnabas was not an apostle. The “work” to which they were now set apart was that of preaching the gospel in the regions round about Antioch. It was not any permanent office in the church, but was a temporary designation to a missionary enterprise in extending the gospel, especially through Asia Minor, and the adjacent regions. Accordingly, when, in the fulfillment of this appointment, they had traveled through Seleucia, Cyprus, Paphos, Pamphylia, Pisidia, etc., they returned to Antioch, having fulfilled the work to which they were separated. See Acts 14:26-27. “Whereunto I have called them.” This proves that they received their commission to this work directly from God the Holy Spirit. Paul and Barnabas had been influenced by the Spirit to engage in this work, but they were to be sent forth by the concurrence and designation of the church.

God had abundantly blessed the labors of Paul and Barnabas during the year they remained with the believers in Antioch. But neither of them had as yet been formally ordained to the gospel ministry. They had now reached a point in their Christian experience when God was about to entrust them with the carrying forward of a difficult missionary enterprise, in the prosecution of which they would need every advantage that could be obtained through the agency of the church. AA 160.1

“There were in the church that was at Antioch certain prophets and teachers; as Barnabas, and Simeon that was called Niger, and Lucius of Cyrene, and Manaen, ... and Saul. As they ministered to the Lord, and fasted, the Holy Ghost said, Separate Me Barnabas and Saul for the work whereunto I have called them.” Before being sent forth as missionaries to the heathen world, these apostles were solemnly dedicated to God by fasting and prayer and the laying on of hands. Thus they were authorized by the church, not only to teach the truth, but to perform the rite of baptism and to organize churches, being invested with full ecclesiastical authority. AA 160.2

The Christian church was at this time entering upon an important era. The work of proclaiming the gospel message among the Gentiles was now to be prosecuted with vigor; and as a result the church was to be strengthened by a great ingathering of souls. The apostles who had been appointed to lead out in this work would be exposed to suspicion, prejudice, and jealousy. Their teachings concerning the breaking down of “the middle wall of partition” (Ephesians 2:14) that had so long separated the Jewish and the Gentile world, would naturally subject them to the charge of heresy, and their authority as ministers of the gospel would be questioned by many zealous, believing Jews. God foresaw the difficulties that His servants would be called to meet, and, in order that their work should be above challenge, He instructed the church by revelation to set them apart publicly to the work of the ministry. Their ordination was a public recognition of their divine appointment to bear to the Gentiles the glad tidings of the gospel. AA 161.1

I saw that we are no more secure from false teachers now than they were in the apostles’ days; and, if we do no more, we should take as special measures as they did to secure the peace, harmony, and union of the flock. We have their example, and should follow it. Brethren of experience and of sound minds should assemble, and following the Word of God and the sanction of the Holy Spirit, should, with fervent prayer, lay hands upon those who have given full proof that they have received their commission of God, and set them apart to devote themselves entirely to His work. This act would show the sanction of the church to their going forth as messengers to carry the most solemn message ever given to men. EW 101.1

God will not entrust the care of His precious flock to men whose mind and judgment have been weakened by former errors that they have cherished, such as so-called perfectionism [see Appendix.] and Spiritualism, and who, by their course while in these errors, have disgraced themselves and brought reproach upon the cause of truth. Although they may now feel free from error and competent to go forth and to teach this last message, God will not accept them. He will not entrust precious souls to their care; for their judgment was perverted while in error, and is now weakened. The great and holy One is a jealous God, and He will have holy men to carry His truth. The holy law spoken by God from Sinai is a part of Himself, and holy men who are its strict observers will alone honor Him by teaching it to others. EW 101.2

The servants of God who teach the truth should be men of judgment. They should be men who can bear opposition and not get excited; for those who oppose the truth will pick at those who teach it, and every objection that can be produced, will be brought in its worst form to bear against the truth. The servants of God who bear the message must be prepared to remove these objections, with calmness and meekness, by the light of truth. Frequently opposers talk to ministers of God in a provoking manner, to call out something from them of the same nature, that they can make as much of it as possible and declare to others that the teachers of the commandments have a bitter spirit and are harsh, as has been reported. I saw that we must be prepared for objections, and with patience, judgment, and meekness, let them have the weight they deserve, not throw them away or dispose of them by positive assertions, and then bear down upon the objector, and manifest a hard spirit toward him; but give the objections their weight, then bring forth the light and the power of the truth, and let it outweigh and remove the errors. Thus a good impression will be made, and honest opposers will acknowledge that they have been deceived and that the commandment keepers are not what they have been represented to be. EW 102.1

God communicated with the devout prophets and teachers in the church at Antioch. “As they ministered to the Lord, and fasted, the Holy Ghost said, Separate me Barnabas and Saul for the work whereunto I have called them.” Acts 13:2. These apostles were therefore dedicated to God in a most solemn manner by fasting and prayer and the laying on of hands; and they were sent forth to their field of labor among the Gentiles. SR 303.1

Both Paul and Barnabas had been laboring as ministers of Christ, and God had abundantly blessed their efforts, but neither of them had previously been formally ordained to the gospel ministry by prayer and the laying on of hands. They were now authorized by the church not only to teach the truth but to baptize and to organize churches, being invested with full ecclesiastical authority. This was an important era for the church. Though the middle wall of partition between Jew and Gentile had been broken down by the death of Christ, letting the Gentiles into the full privileges of the gospel, the veil had not yet been torn away from the eyes of many of the believing Jews, and they could not clearly discern to the end of that which was abolished by the Son of God. The work was now to be prosecuted with vigor among the Gentiles, and was to result in strengthening the church by a great ingathering of souls. SR 303.2