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Preach the word - Κηρυξον τον λογον· Proclaim the doctrine, the doctrine of Christ crucified, for the sins of the whole world; the doctrine, that the Gentiles are invited to be fellow heirs with the Jews, and that for Jews and Gentiles there is no salvation but by faith in Christ.

Be instant in season, out of season - Επιστηθι ευκαιρως, ακαιρως . Be urgent whether the times be prosperous or adverse, whenever there is an opportunity; and when there is none, strive to make one. The Judge is at the door, and to every man eternity is at hand! Wherever thou meetest a sinner, speak to him the word of reconciliation. Do not be contented with stated times and accustomed places merely; all time and place belong to God, and are proper for his work. Wherever it can be done, there it should be done. Satan will omit neither time nor place where he can destroy. Omit thou none where thou mayest be the instrument of salvation to any.

Reprove - Ελεγξον· Confute, the false teacher.

Rebuke - Επιτιμησον· Reprove cuttingly and severely those who will not abandon their sins.

Exhort - Παρακαλεσον· Comfort the feeble-minded, the diffident and the tempted.

With all long-suffering - In reference to each and all of these cases.

And doctrine - The different modes of teaching suited to each.

Preach the word - The Word of God; the gospel. This was to be the main business of the life of Timothy, and Paul solemnly charges him in view of the certain coming of the Redeemer to judgment, to be faithful in the performance of it.

Be instant - see the notes at Romans 12:12. The meaning here is, that he should be constant in this duty. Literally, “to stand by, or to stand fast by;” that is, he was to be pressing or urgent in the performance of this work. He was always to be at his post, and was to embrace every opportunity of making known the gospel. What Paul seems to have contemplated was not merely, that he should perform the duty at stated and regular times; but that he should press the matter as one who had the subject much at heart, and never lose an opportunity of making the gospel known.

In season - εὐκαίρως eukairōsIn good time; opportunely; compare Matthew 26:16; Luke 22:6; Mark 14:11. The sense is, when it could be conveniently done; when all things were favorable, and when there were no obstructions or hindrances. It may include the “stated and regular” seasons for public worship, but is not confined to them.

Out of season - ἀκαίρως akairōsThis word does not elsewhere occur in the New Testament. It is the opposite of the former, and means that a minister is to seek opportunities to preach the gospel even at such periods as might be inconvenient to himself, or when there might be hindrances and embarrassments, or when there was no stated appointment for preaching. He is not to confine himself to the appointed times of worship, or to preach only when it will be perfectly convenient for himself, but he is to have such an interest and earnestness in the work, that it will lead him to do it in the face of embarrassments and discouragements, and whenever he can find an opportunity. A man who is greatly intent on an object will seek every opportunity to promote it. He will not confine himself to stated times and places, but will present it everywhere, and at all times. A man, therefore, who merely confines himself to the stated seasons of preaching the gospel, or who merely preaches when it is convenient to himself, should not consider that he has come up to the requirement of the rule laid down by the apostle. He should preach in his private conversation, and in the intervals of his public labors, at the side of the sick bed, and wherever there is a prospect of doing good to any one. If his heart is full of love to the Saviour and to souls, he cannot help doing this.

Reprove - Or “convince;” See the notes at 2 Timothy 3:16. The meaning is that he was to use such arguments as would “convince” men of the truth of religion, and of their own need of it.

Rebuke - Rebuke offenders; Titus 2:15; see the use of the word in Matthew 8:26; Matthew 12:16, (rendered “charged”); Matthew 16:22; Matthew 17:18; Matthew 19:13; Matthew 20:31; Luke 4:35, Luke 4:39; Luke 17:13; Luke 18:15; Jude 1:9. In the New Testament the word is used to express a judgment of what is wrong or contrary to one‘s will, and hence, to admonish or reprove. It implies our conviction that there is something evil, or some fault in him who is rebuked. The word in this verse rendered “reprove,” does not imply this, but merely that one may be in error, and needs to have arguments presented to convince him of the truth. That word also implies no superior authority in him who does it. He presents “reasons, or argues” the case, for the purpose of convincing. The word here rendered rebuke, implies authority or superiority, and means merely that we may say that a thing is wrong, and administer a rebuke for it, as if there were no doubt that it was wrong. The propriety of the rebuke rests on our authority for doing it, not on the arguments which we present. This is based on the presumption that men often Know that they are doing wrong, and need no arguments to convince them of it. The idea is, that the minister is not merely to reason about sin, and convince men that it is wrong, but he may solemnly admonish them not to do it, and warn them of the consequences.

Exhort - See the notes at Romans 12:8.

With all long-suffering - That is, with a patient and persevering spirit if you are opposed; see the notes on 2 Timothy 2:25; compare the notes on Romans 2:4; compare Romans 9:22; 2 Corinthians 6:6; Galatians 5:22; Ephesians 4:2; Colossians 1:11; Colossians 3:12; 1 Timothy 1:16.

And doctrine - Teaching, or patient instruction.

I charge thee therefore before God, and the Lord Jesus Christ, who shall judge the quick and the dead at his appearing and his kingdom; preach the word; be instant in season, out of season; reprove, rebuke, exhort with all longsuffering and doctrine. 2 Timothy 4:1, 2. CC 347.1

Prophecies Already Made Plain—The Lord wants all to understand His providential dealings now, just now, in the time in which we live. There must be no long discussions, presenting new theories in regard to the prophecies which God has already made plain. Now the great work from which the mind should not be diverted is the consideration of our personal safety in the sight of God. Are our feet on the rock of ages? Are we hiding ourselves in our only refuge? The storm is coming, relentless in its fury. Are we prepared to meet it? Are we one with Christ as He is one with the Father? Are we heirs of God and joint heirs with Christ? Are we working in copartnership with Christ?—Manuscript 32a, 1896. Ev 199.1

Teach Lessons of Christ—The apostle presents a solemn charge to every minister of the gospel. He arrays them before God and the Lord Jesus Christ, who shall judge the quick and the dead, to preach the Word, and they are not to show a partiality for merely the prophecies and the argumentative portions of the Scriptures, but the greatest and most important lessons that are given us are those given us by Jesus Christ Himself.—Manuscript 13, 1888. Ev 199.2

“I charge thee therefore,” Paul wrote to Timothy, “before God, and the Lord Jesus Christ, who shall judge the quick and the dead at His appearing and His kingdom: Preach the word; be instant in season, out of season; reprove, rebuke, exhort with all long-suffering and doctrine.” [2 Timothy 4:1, 2.] GW 30.1

This solemn charge to one so zealous and faithful as was Timothy, is a strong testimony to the importance and responsibility of the work of the gospel minister. Summoning Timothy before the bar of God, Paul bids him preach the word, not the sayings and customs of men; to be ready to witness for God whenever opportunity should present itself,—before large congregations and private circles, by the way and at the fireside, to friends and to enemies, whether in safety or exposed to hardship and peril, reproach and loss. GW 30.2

“Giving no offense in anything, that the ministry be not blamed.”